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  1. JACS
    UNUSUAL REARRANGEMENT OF AN
    N-DONOR-FUNCTIONALIZED N-HETEROCYCLIC
    CARBENE LIGAND ON GROUP 8 METALS
    The Song group discovered an unusual rearrangement reaction,where
    the N,C-chelate ligand of a piano-stool Group 8complex isomerizes into
    an N,N-chelate ligand. Mechanistic study suggests the involvement of a
    high-energy metal-alkylidene intermediate.
    Song group, Journal of the American Chemical Society, 2018
  2. Cell
    DYSREGULATION OF MITOCHONDRIAL CLPP
    PROTEASE AS A POTENTIAL STRATEGY TO
    DEVELOP NOVEL ANTICANCERS
    Human mitochondrial ClpP was found to be activated by specific
    acyldepsipeptide compounds causing apoptotic cell death.
    Houry and Batey groups, Cell Chemical Biology, 2018
  3. Nature
    AMINE HEMILABILITY ENABLES BORON TO
    MECHANISTICALLY RESEMBLE EITHER
    HYDRIDE OR PROTON
    Mechanistic studies of the hemilability of MIDA
    (N-methyliminodiacetic acid) boronates reveal the chameleonic
    behaviour of the BMIDA group.
    Yudin group, Nature Chemistry, 2018
  4. Nature
    TIPPING CELL SIGNALING PATHWAYS BY SALTS
    Mechanistic insights into allosteric regulation ofthe A2A adenosine
    G protein-coupled receptor byphysiological cations.
    Prosser group, Nature Communications, 2018
  5. Journal of the American Chemical Society
    COMPETITIVE SELF-ASSEMBLY KINETICS AS A
    ROUTE TO CONTROLLING MORPHOLOGY OF
    CORE-CRYSTALLINE CYLINDRICAL MICELLESS
    One can manipulate the seeded-growth kinetics of block
    copolymer unimers to control the growth sequence of
    unimers and thus the comicelle morphology.
    Winnik group, Journal of the American Chemical Society, 2018
  6. Oncogene
    INHIBITING MYC BINDING TO THE E-BOX DNA
    MOTIF BY ME47 DECREASES
    TUMOUR XENOGRAFT GROWTH
    The Shin lab's designed protein ME47 decreased tumor growth in
    a triple negative breast cancer mouse model, a type of cancer with
    no effective treatments.
    Shin, Chan & Penn groups, Oncogene, 2017

Awards:

Mike Dymarski named 'Fellow of Sustainable Labs Canada'

Mike Dymarski named 'Fellow of Sustainable Labs Canada'

Congratulations to Mike Dymarski for being named a Fellow of Sustainable Labs Canada. Mike is being recognized for his significant contribution throughout his career to the cause of laboratory sustainability and as a founding member of the Sustainable Laboratories of Canada association. Mike received this honour at a ceremony at the Canadian Museum for Human Rights during the SLCan Congress in Winnipeg.


News and Announcements:

Chemistry collaborations for early career scientists

Chemistry collaborations for early career scientists

Rachel Hems, a 5th-year PhD student in the Abbatt Group, had a unique opportunity this fall to be part of a small group of early career scientists hoping to forge international collaborations in their fields.

Rachel was invited to participate in the 2018 iCACGP/IGAC Early Career Short Course in Shodoshima, Japan. She was one of only 40 early career atmospheric scientists to attend the three-day course. The sessions ranged in topic from science policy to the future of atmospheric chemistry.


U of T Solar Fuels Group joins final of the Carbon XPRIZE

U of T Solar Fuels Group joins final of the Carbon XPRIZE

The University of Toronto Solar Fuels group, led by Professor Geoff Ozin has recently joined C4X, an NRG COSIA Carbon XPRIZE finalist, in their effort to create viable carbon dioxide utilization technologies.

This new partnership brings together several large emitters and technology providers, enabling a clear path forward for validation of new carbon-reducing technologies on an industrial scale.


Professor Barbara Sherwood Lollar: NASA should be looking underground for extraterrestrial life

Professor Barbara Sherwood Lollar: NASA should be looking underground for extraterrestrial life

Professor Barbara Sherwood Lollar spoke with Discover Magazine this month, where she says that the search for life on other planets needs a new model, a model where we don't assume that life will be found in similar environments to what we find on earth.

“We need to make sure that our toolbox of biosignatures is universal enough that it encompasses both our ability to recognize life as we know it, but also our ability to recognize life as we don’t know it,” said Lollar.


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Optimizing NMR Methods for Structure Elucidation: Characterizing Natural Products and Other Organic Compounds
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