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  1. Oncogene
    INHIBITING MYC BINDING TO THE E-BOX DNA
    MOTIF BY ME47 DECREASES
    TUMOUR XENOGRAFT GROWTH
    The Shin lab's designed protein ME47 decreased tumor growth in
    a triple negative breast cancer mouse model, a type of cancer with
    no effective treatments.
    Shin, Chan & Penn groups, Oncogene, 2017
  2. DNA
    PROTEIN DIMERIZATION PARTNERS ARE DICTATED
    BY THE DNA TARGET, NOT PROTEIN TARGET
    Many genes are regulated by protein hetero- or homodimers. Shin et
    al found that DNA bases outside the protein-DNA recognition target
    determine the protein dimerization partner.
    Shin Group, Molecular Biosystems, January 2017
  3. THE ROLE OF DIMER ASYMMETRY AND
    PROTOMER DYNAMICS IN ENZYME CATALYSIS
    Prosser and coauthor Pai examine a homodimeric enzyme, fluoroacetate
    dehalogenase, which converts a highly toxic pesticide into a harmless
    metabolite, and explore the role of enzyme dynamics in the process.
    Prosser Group, Science, January 2017
  4. Graphical depiction of overall 2D scheme of coated gold microelectrode.
    BIOFOULING-RESISTANT [K+]o SENSOR
    FOR MONITORING EPILEPSY
    A novel approach for in vivo spatio-temporal measurements of [K+]o
    using multichannel monolayer coated gold microelectrodes reveals
    new physiological events not previously seen during seizures in mice.
    Thompson Group, Biosensors, December 2016
  5. SOLAR POWERED REVERSE WATER
    GAS SHIFT REACTION
    The role of defects on the electronic & photocatalytic properties of
    In2O3-x(OH)y NPs for the reverse water-gas shift reaction are revealed,
    a key advance towards efficient catalysts for the CO2 reduction reaction.
    Ozin Group, PNAS, December 2016
  6. Macrocyclization reaction between a linear peptide, an aldehyde and (N-isocyanimino)triphenylphosphorane.
    OXADIAZOLE GRAFTS IN PEPTIDE
    MACROCYCLES
    A new macrocyclization reaction delivers cyclic molecules for
    exploration in drug discovery.
    Yudin Group, Nature Chemistry, December 2016
  7. Figure showing a high degree of bond-selectivity dependent on adsorbate bond alignment.
    BOND SELECTIVE REACTION
    Kelvin Anggara, Kai Huang and Lydie Leung in Polanyi's group
    have shown and explained a hundredfold bond-selectivity in
    electron-induced reaction at a smooth metal surface.
    Polanyi Group, Nature Communications, December 2016

Awards:

Professor Aaron Wheeler named Tier 1 Canada Research Chair

Professor Aaron Wheeler named Tier 1 Canada Research Chair

We are pleased to announce that Professor Aaron Wheeler has been named Tier 1 Canada Research Chair in Microfluidic Bioanalysis. Aaron is one of five new Tier 1 Canada Research Chairs at the University of Toronto announced by the federal government earlier this week.


News and Announcements:

Ontario names Professor Molly Shoichet as province's first Chief Scientist

Ontario names Professor Molly Shoichet as province's first Chief Scientist

Congratulations to Professor Molly Shoichet who has been named as Ontario's first Chief Scientist. In this role, Shoichet will lend her efforts to advancing science and innovation in the province. As Chief Scientist, Shoichet will also be asked to help increase the use of scientific evidence in decision-making across government ministries and promote the value of science while strengthening public trust in science.

 


Professor Geoffrey Ozin's team advances to ‘close the carbon cycle’

Professor Geoffrey Ozin's team advances to ‘close the carbon cycle’

Making fuel out of polluted air, using it to power industry, and then taking the emissions from that industry back out of the air to create more fuel sounds too good to be true. But, while there are a few hurdles to clear, a team led by Professor Geoffrey Ozin is getting closer to closing the carbon cycle.

 

 

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FLP reactivity of [Ph 3 C] + and ( o -tolyl) 3 P and the capture of a Staudinger reaction intermediate
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