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  1. Oncogene
    INHIBITING MYC BINDING TO THE E-BOX DNA
    MOTIF BY ME47 DECREASES
    TUMOUR XENOGRAFT GROWTH
    The Shin lab's designed protein ME47 decreased tumor growth in
    a triple negative breast cancer mouse model, a type of cancer with
    no effective treatments.
    Shin, Chan & Penn groups, Oncogene, 2017
  2. DNA
    PROTEIN DIMERIZATION PARTNERS ARE DICTATED
    BY THE DNA TARGET, NOT PROTEIN TARGET
    Many genes are regulated by protein hetero- or homodimers. Shin et
    al found that DNA bases outside the protein-DNA recognition target
    determine the protein dimerization partner.
    Shin Group, Molecular Biosystems, January 2017
  3. THE ROLE OF DIMER ASYMMETRY AND
    PROTOMER DYNAMICS IN ENZYME CATALYSIS
    Prosser and coauthor Pai examine a homodimeric enzyme, fluoroacetate
    dehalogenase, which converts a highly toxic pesticide into a harmless
    metabolite, and explore the role of enzyme dynamics in the process.
    Prosser Group, Science, January 2017
  4. Graphical depiction of overall 2D scheme of coated gold microelectrode.
    BIOFOULING-RESISTANT [K+]o SENSOR
    FOR MONITORING EPILEPSY
    A novel approach for in vivo spatio-temporal measurements of [K+]o
    using multichannel monolayer coated gold microelectrodes reveals
    new physiological events not previously seen during seizures in mice.
    Thompson Group, Biosensors, December 2016
  5. SOLAR POWERED REVERSE WATER
    GAS SHIFT REACTION
    The role of defects on the electronic & photocatalytic properties of
    In2O3-x(OH)y NPs for the reverse water-gas shift reaction are revealed,
    a key advance towards efficient catalysts for the CO2 reduction reaction.
    Ozin Group, PNAS, December 2016
  6. Macrocyclization reaction between a linear peptide, an aldehyde and (N-isocyanimino)triphenylphosphorane.
    OXADIAZOLE GRAFTS IN PEPTIDE
    MACROCYCLES
    A new macrocyclization reaction delivers cyclic molecules for
    exploration in drug discovery.
    Yudin Group, Nature Chemistry, December 2016
  7. Figure showing a high degree of bond-selectivity dependent on adsorbate bond alignment.
    BOND SELECTIVE REACTION
    Kelvin Anggara, Kai Huang and Lydie Leung in Polanyi's group
    have shown and explained a hundredfold bond-selectivity in
    electron-induced reaction at a smooth metal surface.
    Polanyi Group, Nature Communications, December 2016

Awards:

Professor Aaron Wheeler named Tier 1 Canada Research Chair

Professor Aaron Wheeler named Tier 1 Canada Research Chair

We are pleased to announce that Professor Aaron Wheeler has been named Tier 1 Canada Research Chair in Microfluidic Bioanalysis. Aaron is one of five new Tier 1 Canada Research Chairs at the University of Toronto announced by the federal government earlier this week.


News and Announcements:

Professor Molly Shoichet named to the Order of Canada

Professor Molly Shoichet named to the Order of Canada

Professor Molly Shoichet, who was made Ontario's first Chief Scientist in the fall, has been named an Officer of the Order of Canada, the second-highest of its three levels. She is cited for her “cutting-edge research in biomedical engineering, and for efforts to promote women in science and to advance scientific literacy.”

 

 


Professor Geoff Ozin's Solar Fuels Team named finalists in 2030 Challenge

Professor Geoff Ozin's Solar Fuels Team named finalists in 2030 Challenge

U of T's Solar Fuels Team, led by Professor Geoff Ozin, has been selected as one of 20 semi-finalists in the Ontario Center of Excellence Solutions 2030 Challenge Phase 1 competition, to find technological solutions to the greenhouse gas emissions problem in Ontario.

 

 


Public funding is needed to support the next generation of scientists: Professor Mark Lautens

Public funding is needed to support the next generation of scientists: Professor Mark Lautens

Young scientists in Canada are facing serious obstacles when it comes to funding, writes Professor Mark Lautens in a Globe and Mail op-ed. “This is an enormous waste of talent and potential,” he says. “It is also likely to do multigenerational damage to innovation in all parts of the Canadian economy.”

 

 


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