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  1. Oncogene
    INHIBITING MYC BINDING TO THE E-BOX DNA
    MOTIF BY ME47 DECREASES
    TUMOUR XENOGRAFT GROWTH
    The Shin lab's designed protein ME47 decreased tumor growth in
    a triple negative breast cancer mouse model, a type of cancer with
    no effective treatments.
    Shin, Chan & Penn groups, Oncogene, 2017
  2. DNA
    PROTEIN DIMERIZATION PARTNERS ARE DICTATED
    BY THE DNA TARGET, NOT PROTEIN TARGET
    Many genes are regulated by protein hetero- or homodimers. Shin et
    al found that DNA bases outside the protein-DNA recognition target
    determine the protein dimerization partner.
    Shin Group, Molecular Biosystems, January 2017
  3. THE ROLE OF DIMER ASYMMETRY AND
    PROTOMER DYNAMICS IN ENZYME CATALYSIS
    Prosser and coauthor Pai examine a homodimeric enzyme, fluoroacetate
    dehalogenase, which converts a highly toxic pesticide into a harmless
    metabolite, and explore the role of enzyme dynamics in the process.
    Prosser Group, Science, January 2017
  4. Graphical depiction of overall 2D scheme of coated gold microelectrode.
    BIOFOULING-RESISTANT [K+]o SENSOR
    FOR MONITORING EPILEPSY
    A novel approach for in vivo spatio-temporal measurements of [K+]o
    using multichannel monolayer coated gold microelectrodes reveals
    new physiological events not previously seen during seizures in mice.
    Thompson Group, Biosensors, December 2016
  5. SOLAR POWERED REVERSE WATER
    GAS SHIFT REACTION
    The role of defects on the electronic & photocatalytic properties of
    In2O3-x(OH)y NPs for the reverse water-gas shift reaction are revealed,
    a key advance towards efficient catalysts for the CO2 reduction reaction.
    Ozin Group, PNAS, December 2016
  6. Macrocyclization reaction between a linear peptide, an aldehyde and (N-isocyanimino)triphenylphosphorane.
    OXADIAZOLE GRAFTS IN PEPTIDE
    MACROCYCLES
    A new macrocyclization reaction delivers cyclic molecules for
    exploration in drug discovery.
    Yudin Group, Nature Chemistry, December 2016
  7. Figure showing a high degree of bond-selectivity dependent on adsorbate bond alignment.
    BOND SELECTIVE REACTION
    Kelvin Anggara, Kai Huang and Lydie Leung in Polanyi's group
    have shown and explained a hundredfold bond-selectivity in
    electron-induced reaction at a smooth metal surface.
    Polanyi Group, Nature Communications, December 2016

Awards:

Professor Mark Lautens awarded the Henry Marshall Tory Medal

Professor Mark Lautens awarded the Henry Marshall Tory Medal

We are pleased to announce that Professor Mark Lautens has been awarded the 2017 Henry Marshall Tory Medal of the Royal Society of Canada. The Henry Marshall Tory Medal, which has been awarded biennially since 1943, recognizes outstanding research in a branch of astronomy, chemistry, mathematics, physics, or an allied science. This award is a well-deserved recognition of Mark’s achievements in advancing knowledge and scholarship in Canada. And he joins Doug Stephan (2013), John Bryan Jones (2001) and John Polanyi (1977) as recipients of this award from the Department of Chemistry.


News and Announcements:

GCI gets behind-the-scenes look at GreenCentre Canada

GCI gets behind-the-scenes look at GreenCentre Canada

This summer, the Green Chemistry Initiative (GCI) at U of T's Department of Chemistry made a visit to GreenCentre Canada. The group of nine graduate students were in Kingston for a crash course on the transition from academia to industry in green chemistry. They learned from experts in the field on everything from product development to patents and intellectual property. We spoke with PhD student and GCI member Julia Bayne about the day.

 


Welcome to Our Incoming Graduate Students of 2017


Welcome to Our Incoming Graduate Students of 2017

We are excited to welcome our 75 incoming graduate students who will be pursuing their research interests at our UTM (Mississauga), UTSc (Scarborough) and St. George (downtown) campuses. (photo by Armando Marquez)

 

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