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  1. Oncogene
    INHIBITING MYC BINDING TO THE E-BOX DNA
    MOTIF BY ME47 DECREASES
    TUMOUR XENOGRAFT GROWTH
    The Shin lab's designed protein ME47 decreased tumor growth in
    a triple negative breast cancer mouse model, a type of cancer with
    no effective treatments.
    Shin, Chan & Penn groups, Oncogene, 2017
  2. DNA
    PROTEIN DIMERIZATION PARTNERS ARE DICTATED
    BY THE DNA TARGET, NOT PROTEIN TARGET
    Many genes are regulated by protein hetero- or homodimers. Shin et
    al found that DNA bases outside the protein-DNA recognition target
    determine the protein dimerization partner.
    Shin Group, Molecular Biosystems, January 2017
  3. THE ROLE OF DIMER ASYMMETRY AND
    PROTOMER DYNAMICS IN ENZYME CATALYSIS
    Prosser and coauthor Pai examine a homodimeric enzyme, fluoroacetate
    dehalogenase, which converts a highly toxic pesticide into a harmless
    metabolite, and explore the role of enzyme dynamics in the process.
    Prosser Group, Science, January 2017
  4. Graphical depiction of overall 2D scheme of coated gold microelectrode.
    BIOFOULING-RESISTANT [K+]o SENSOR
    FOR MONITORING EPILEPSY
    A novel approach for in vivo spatio-temporal measurements of [K+]o
    using multichannel monolayer coated gold microelectrodes reveals
    new physiological events not previously seen during seizures in mice.
    Thompson Group, Biosensors, December 2016
  5. SOLAR POWERED REVERSE WATER
    GAS SHIFT REACTION
    The role of defects on the electronic & photocatalytic properties of
    In2O3-x(OH)y NPs for the reverse water-gas shift reaction are revealed,
    a key advance towards efficient catalysts for the CO2 reduction reaction.
    Ozin Group, PNAS, December 2016
  6. Macrocyclization reaction between a linear peptide, an aldehyde and (N-isocyanimino)triphenylphosphorane.
    OXADIAZOLE GRAFTS IN PEPTIDE
    MACROCYCLES
    A new macrocyclization reaction delivers cyclic molecules for
    exploration in drug discovery.
    Yudin Group, Nature Chemistry, December 2016
  7. Figure showing a high degree of bond-selectivity dependent on adsorbate bond alignment.
    BOND SELECTIVE REACTION
    Kelvin Anggara, Kai Huang and Lydie Leung in Polanyi's group
    have shown and explained a hundredfold bond-selectivity in
    electron-induced reaction at a smooth metal surface.
    Polanyi Group, Nature Communications, December 2016

Awards:

Professor Aaron Wheeler named Tier 1 Canada Research Chair

Professor Aaron Wheeler named Tier 1 Canada Research Chair

We are pleased to announce that Professor Aaron Wheeler has been named Tier 1 Canada Research Chair in Microfluidic Bioanalysis. Aaron is one of five new Tier 1 Canada Research Chairs at the University of Toronto announced by the federal government earlier this week.


News and Announcements:

Professor John Polanyi: 'Canada must stop being dismissive of a nuclear ban'

Professor John Polanyi: 'Canada must stop being dismissive of a nuclear ban'

Professor John Polanyi is one of more than a 1,000 members of the Order of Canada who have called for Canada to support nuclear disarmament. Earlier this month, Polanyi spoke on Parliament Hill to address Canada's dismissal of a nuclear ban. "Behaviour in regard to nuclear weapons can certainly change. But for this to happen, we shall need a tidal wave of new thinking, to which this ripple from the Order of Canada will now contribute," he said.


Professor John Polanyi calls for more government investment in science

Professor John Polanyi calls for more government investment in science

Professor John Polanyi delivered the keynote address this week at a Canada 150 event on the future of Canadian federalism. In an interview with U of T News after the event, Polanyi turned his attention to the future of research and discovery in Canada, speaking in support of the recommendations of Canada’s Fundamental Science Review panel. Polanyi says the government funding he received throughout his career “has been absolutely vital” and crucially, it was given “on very enlightened terms".


Unexpected Opportunities: Professor Mark Lautens

Unexpected Opportunities: Professor Mark Lautens

Professor Mark Lautens was invested into the Order of Canada in November, 2015. He was recently asked to share his experience since being named an Officer. "It goes without saying that the Order of Canada is a singular honour," says Lautens. "An entirely unexpected bonus to receiving the Order came in the form of an invitation to preside over citizenship ceremonies."

 



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